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Synthesis and Medical Application of 3D Graphene Materials the incorporation of a large volume of drugs, hydrophilic and lipophilic drugs can be loaded on the surface and inside the CNTs, multi drugs are loaded onto the CNTs in the case of multidrug therapies. Interestingly, drugs loaded on the surface of the CNTs can recognize specific receptors present on the surface of the cell thereby crossing the cellular barrier by endocytosis or through other mechanisms without producing toxic effects (Hassan et al., 2020). This method has been very effective in the delivery of several anticancer drugs like methotrexate 1, epirubicin 2, and doxorubicin 3 by binding on the CNTs and their efficacy has been checked in vivo and in vitro for the treatment of cancer cells (Chen et al., 2011). Figure 16. Molecular Structure Some Anticancer Drugs: (1) Methotrexate, (2) Epirubicin, (3) Doxorubicin Figure 17. The Delivery of Drugs Using Carbon Nanotubes (CNTs) (Hassan et al., 2020) Tissue Engineering Tissue engineering is interdisciplinary as this branch of science combines the specialities of the biologist, the chemist, and the material scientist to work together in understanding the polymer- cell interactions, the effect of scaffolds on the human body, and the design of scaffolds for higher seeding efficiency. The basic concept (Figure 18) of tissue engineering is that the whole cycle may consist of extracting the cell from the body, cell biopsy, monolayer cell culture, proliferated cells, scaffold fabrication, and remodelling of the extracellular matrix (Hassan et al., 2020). 2534|Indonesian Journal of Multidisciplinary Science, 2(5), Feb, 2023PDF Image | Medical Application of 3D Graphene
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