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Synthesis and Medical Application of 3D Graphene Materials Figure 18. The Basic Principles and Cycle of Tissue Engineering (Ambekar & Kandasubramanian, 2019) Gong and co-workers developed a novel Graphene Oxide modified 3D acellular cartilage extracellular matrix (ACM)scaffold for cartilage regeneration. The ACM which was like that of a natural tissue was evaluated in vitro to bridge the cartilage injury of the knee of a Rabbit (Figure 19). The composite ACM scaffold modified promoted good cell adhesion and proliferation including chondrogenic differentiation in vitro, it also had good biocompatibility and a mild inflammatory response. The materials used for the modification of the ACM scaffold were sources from full-thickness cartilage of the distal femoral condyle of market-wight pig together with other reagents purchased from Sigma-Aldrich. This kind of tissue regeneration is imperative and useful as the population is ageing with an increased number of people exercising and many patients are having cartilage injuries as a result (Ambekar & Kandasubramanian, 2019). Figure 19. Schematic Showing the Preparation and Application of the graphene scaffold (Gong et al., 2021) Similarly, Bone tissue engineering has also been achieved, bone tissue regeneration has been fabricated by a tabular poly-L-lactic acid (PLLA) 4 scaffold through thermally induced separation. Biocompatibility, cytocompatibility, and bioactivities have been recorded for this method of bone cell regeneration. Several other bone regeneration techniques were reported, including the engineering of organs like the liver, cardiac tissues (Raslan et al., 2020), neural tissues, and skin tissue engineering (Ambekar & Kandasubramanian, 2019). 2535|Indonesian Journal of Multidisciplinary Science, 2(5), Feb, 2023PDF Image | Medical Application of 3D Graphene
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