PDF Publication Title:
Text from PDF Page: 014
Molecules 2014, 19 20104 nanoparticles have also been employed to encapsulate curcumin, for efficient delivery of curcumin. Due to their selective accumulations and ability to cause hyperthermia, MNP-curcumin with suitable modifications are attracting the attention of many researchers for specific application in cancer therapy and diagnosis. Figure 4. Polymer stabilized curcumin functionalized iron oxide magnetic nanoparticles. Iron oxide nanoparticle Curcumin molecules polymer molecules 8. Conclusions and Future Directions Curcumin is a specially gifted molecule provided by Mother-Nature to protect humans from chronic health problems. Looking at the simple chemical structure of curcumin, it is natural to presume that chemistry of curcumin is also very simple, however with increasing scientific understanding it appears to be more complex, unique and difficult to comprehend. It is a symmetric molecule abundant in turmeric with relatively high stability in natural form. It has an intense yellow color, that changes to deep red in basic pH solution. In simple aqueous and aqueous-organic solutions, it is susceptible to fast degradation, which increases as the basicity of the solutions increases, and also on exposure to sunlight. The metabolic products of curcumin are different from the degradation products, where O-conjugation and reduction are the important processes initiated through the enzymatic reactions. Interestingly unlike the degradation products, the metabolic products are much more difficult to synthesize in the laboratory. The presence of α,β-unsaturated structure makes curcumin participate in nucleophilic addition reactions with protein thiols and selenols, that play important role in modulating cellular oxidative stress. It is still not clear if these processes are reversible under physiological conditions. Future chemical research on these aspects is necessary to elucidate the kinetics and mechanism of all these reactions, so that a meaningful conclusion can be made on the role of these different processes in curcumin biology. Recently there is a surge of activity on preparation and characterization of curcumin-metal complexes due to the strong affinity of β-diketo moiety as an efficient metal chelator. Although it is confirmed that curcumin reduces metal toxicity in living systems through complexation, the actual role of these metal complexes in curcumin biology appears to be complex and unclear. Detailed research is warranted on structure-activity evaluation of the curcumin-metal-complexes in solution. Problems associated with curcumin bioavailability could be overcome to a great extent through formulations with natural biopolymers, which find practical application as nutritional products. Recent research is now focused on developing conjugates of curcumin with metal and metal oxide nanoparticles and some of these formulations have promising potential in nanomedicine with additional effects of inducing targeted hyperthermia in cancer cells. They are also attracting interest as diagnostic tools for Alzheimer’s disease and also as MRI contrast agents. Overall it appears that even though there has beenPDF Image | Curcumin: From Extraction to Therapeutic Agent
PDF Search Title:
Curcumin: From Extraction to Therapeutic AgentOriginal File Name Searched:
molecules-19-20091.pdfDIY PDF Search: Google It | Yahoo | Bing
CO2 Organic Rankine Cycle Experimenter Platform The supercritical CO2 phase change system is both a heat pump and organic rankine cycle which can be used for those purposes and as a supercritical extractor for advanced subcritical and supercritical extraction technology. Uses include producing nanoparticles, precious metal CO2 extraction, lithium battery recycling, and other applications... More Info
Heat Pumps CO2 ORC Heat Pump System Platform More Info
CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com (Standard Web Page)