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Molecules 2014, 19 20105 significant progress in the chemistry of curcumin, a great deal can still be expected from chemists to exploit this divine natural product as a therapeutic remedy for many chronic diseases. Acknowledgments The author is grateful to many of the students and colleagues whose names appeared as co-authors in the publications for help and useful discussions on curcumin research. The encouragement and support for this research by the Department of Atomic Energy, Government of India is acknowledged. Conflict of Interest The author declares no conflict of interest. References 1. Aggarwal, B.B.; Kumar, A.; Bharti, A.C. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 2003, 23, 363–398. 2. Wilken, R.; Veena, S.M.; Wang, M.B.; Srivatsan, E.S. Curcumin: A review of anticancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer 2011, 10, 1–19. 3. Grykiewicz, G.; Silfirski, P. Curucmin and curcuminoids in quest for medicinal status. Acta Biochim. Pol. 2012, 59, 201–212. 4. Esatbeyoglu, T.; Huebbe, P.; Insa, M.A.; DawnChin, E.; Wagner, A.E.; Rimbach, G. Curcumin—From Molecule to Biological Function. Angew. Chem. Int. Ed. 2012, 51, 5308–5332. 5. Gupta, S.; Prasad, S.; Ji, H.K.; Patchva, S.; Webb, L.J.; Priyadarsini, K.I.; Aggarwal, B.B. Multitargeting by curcumin as revealed by molecular interaction studies. Nat. Prod. Rep. 2011, 28, 1937–1955. 6. Priyadarsini, K.I. Chemical and structural features influencing the biological activity of curcumin. Curr. Pharm. Des. 2013, 19, 2093–2100. 7. Vogel, H.A.; Pelletier, J. Curcumin-biological and medicinal properties. J. Pharma 1815, 2, 50. 8. Sharma, O.P. Antioxidant activity of curcumin and related compounds. Biochem. Pharmacol. 1976, 25, 1811–1812. 9. Singh, S.; Aggarwal, B. Activation of transcription factor NF-κB is suppressed by curcumin (Diferuloylmethane). J. Biol. Chem. 1995, 270, 24995–25000. 10. Ramanjaneyulu, P.S.; Sayi, Y.S.; Raman, V.A.; Ramakumar, K.L. Spectrophotometric determination of boron in nuclear grade uranium compounds with curcumin and studies on effect of HNO3. J. Radioanal. Anal. Nucl. Chem. 2007, 274, 109–114. 11. Paulucci, V.P.; Couto, R.O.; Teixeira, C.C.C.; Freitas, L.A.P. Optimization of the extraction of curcumin from Curcuma longa rhizomes. Braz. J. Pharmacogn. 2013, 23, 94–100. 12. Lee, K.J.; Yang, H.J.; Jeong, S.W.; Ma, J.Y. Solid-phase extraction of curcuminoid from turmeric using physical process method. Korean J. Pharmacogn. 2012, 43, 250–256.PDF Image | Curcumin: From Extraction to Therapeutic Agent
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