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Curcumin: From Extraction to Therapeutic Agent

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Curcumin: From Extraction to Therapeutic Agent ( curcumin-from-extraction-therapeutic-agent )

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Molecules 2014, 19 20108 47. Tønnesen, H.H.; de Vries, H.; Karlsen, J.; Henegouwen, B.V. Studies on curcumin and curcuminoids IX: Investigation of the photobiological activity of curcumin using bacterial indicator systems. J. Pharm. Sci. 1987, 76, 371–373. 48. Singh, U.; Verma, S.; Ghosh, H.N.; Rath, M.C.; Priyadarsini, K.I.; Sharma, A.; Pushpa, K.K.; Sarkar, S.K.; Mukherjee, T. Photo-degradation of curcumin in the presence of TiO2 nanoparticles: Fundamentals & application. J. Mol. Catal. A 2010, 318, 106–111. 49. Asai, A.; Miyazawa, T. Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma. Life Sci. 2000, 67, 2785–2793. 50. Ireson, C.R.; Jones, D.J.L.; Orr, S.; Coughtrie, M.W.H.; Boocock, D.J.; Williams, M.L.; Farmer, P.B.; Steward, W.P.; Gesher, A.J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemol. Biomark. Prev. 2002, 11, 105–111. 51. Wahlstrom, B.; Blennow, G. A study on the fate of curcumin in the rat. Acta Pharmacol. Toxicol. 1978, 43, 86–92. 52. Garcea, G.; Jones, D.J.; Singh, R.; Dennison, A.R.; Farmer, P.B.; Sharma, R.A.; Steward, W.P.; Gescher, A.J.; Berry, D.P. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br. J. Cancer 2004, 90, 1011–1015. 53. Hoehle, S.I.; Pfeiffer, E.; Solyom, A.M.; Metzler, M. Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. J. Agric. Food Chem. 2006, 54, 756–764. 54. Awasthi, S.; Pandya, U.; Singhal, S.S.; Lin, J.T.; Thiviyanathan, V.; Seifert, W.E.; Awasthi, Y.C.; Ansari, G.A. Curcumin-glutathione interactions and the role of human glutathione S-transferase PI-1. Chem. Biol. Int. 2000, 128, 19–38. 55. Lersel, M.L.; Ploemen, J.P.; Struik, I.; van Amersfoort, C.; Keyzer, A.E.; Schefferlie, J.G.; van Bladeren, P.J. Inhibition of glutathione S-transferase activity in human melanoma cells by α,-β unsaturated carbonyl derivatives. Chem. Biol. Int. 1996, 102, 117–132. 56. Fang, J.; Jun, L.; Holmegren, A. Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity. J. Biol. Chem. 2005, 280, 25284–25290. 57. Jung, Y.; Xu, W.; Kim, H.; Ha, N.; Neckers, L. Curcumin-induced degradation of ErbB2: A role for the ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochim. Biophys. Acta Mol. Cell Res. 2007, 1773, 383–390. 58. Li, W.; Wu, W.; Yu, F.; Huang, H.; Liang, X.; Ye, J. Catalytic asymmetric Michael addition with curcumin derivative. Org. Biomol. Chem. 2011, 9, 2505–2511. 59. Dutta, S.; Padhye, S.; Priyadarsini, K.I.; Newton, C. Antioxidant and antiproliferative activity of curcumin semicarbazone derivative. Bio-Org. Med. Chem. 2005, 15, 2738–2744. 60. Simoni, D.; Rizzi, M.; Rondanin, R.; Baruchello, R.; Marchetti, P.; Invidiata, F.P.; Labbozzetta, M.; Poma, P.; Carina, V.; Notarbartolo, M.; et al. Antitumor effects of curcumin and structurally modified b-diketone analogs on multidrug resistant cancer cells. Bioorganic Med. Chem. Lett. 2008, 18, 845–849. 61. Ferrari, E.; Asti, M.; Benassi, R.; Francesca, P.; Saladini, M. Metal binding ability of curcumin derivatives: A theoretical vs. experimental approach. Dalton Trans. 2013, 42, 5304–5313. 62. Pallikkavil, R.; Ummathur, M.S.; Sreedharan, S.; Krishnankutty, K. Synthesis, characterization and antimicrobial studies of Cd(II), Hg(II), Pb(II), Sn(II) and Ca(II) complexes of curcumin. Main Group Metal Chem. 2013, 36, 123–127.

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