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4 Conclusion Curcumin, a naturally occurring phytochemical responsible for the colour of turmeric shows a wide range of pharmacological properties including antioxidant, anti-inflammatory and anti-cancer effects. Continuing the investigation on the activity of the curcumin, here we report its application for the interaction with dsDNA in the presence of Cu(II), using carbon paste electrode and hanging mercury drop electrode. It is shown that differential pulse adsorptive transfer voltammetry can be used in order to study the effects of chemical substance into the DNA structure. The proposed method is sensitive, fast and low cost. Curcumin in the presence of Cu(II) causes damage in DNA through generation of reactive oxygen species, particularly the hydroxyl radical [34]. The DNA damage is the consequence of binding of Cu(II) on the curcumin molecule. The interaction dsDNA with CC-Cu(II) complex is shown to be time dependent and the optimal reaction time was investigated. In addition, the present results suggest a new approach for the detection of toxic and potentially toxic metals. Based on the results, this work could be potentially useful for further investigation for the interaction between curcumin and some toxic elements in relation to dsDNA, knowing the electrochemical behavior of curcumin in the presence of Cu(II). Acknowledgement 9PDF Image | Electroanalytical dsDNA and curcumin vs copper
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