PDF Publication Title:
Text from PDF Page: 023
ceramics in biomedicine Heartening advancements—potential of inhalable particles to treat cardiovascular diseases In a new open-access paper, researchers from institutions in Italy, Greece, and Malaysia explored the development of inhal- able drug-loaded calcium phosphate nanoparticles for treating myocardial cells in the heart. An inhalable vaccine has several perceived benefits to an injectable vaccine, including halting infection at the body’s point of entry; requires lower doses; can be administered through disposable devices; and potentially, when stored in a dry powder form, could be kept stable for much longer than injectable liquid vaccines. While some inhalable medicines such as epinephrine for treating mild symptoms of asthma are well established, researchers continue to investigate what other medicines could be modified for inhalable delivery as well. Peptide therapeutics is one treatment that is ripe for inves- tigation. Peptides are essentially smaller versions of proteins. They are of particular interest as therapeutic drugs because the body naturally produces many different peptides, thus therapeutic peptides are relatively well-tolerated and have fewer side-effects than other pharmaceutical compounds. However, despite an increasing interest in peptide therapeutics, injec- tion remains the main method for peptide delivery. In 2018, some of the Italian authors of the recent study published an article that explored whether inhalation could be an effective method for delivering therapeutic peptides to the heart. They specifically looked at using calcium phos- phate nanoparticles to carry the peptides because of the material’s biocompatibility, biodegradability, and ability to cross the cardiomyocyte cellular membrane, which they dem- onstrated in a 2016 paper. The results of the 2018 study were promising—the peptide- loaded calcium phosphate nanoparticles successfully restored cardiac function in a mouse model. However, the research- ers identified some limitations that needed to be addressed in future studies. Specifically, they acknowledged difficulties with controlling the size of peptide-loaded calcium phosphate nanoparticles before and after delivery. In the new open-access paper, the researchers collaborated with colleagues in Greece and Malaysia to address the tran- sient particle size challenge by turning the nanoparticles into a microparticulate dry powder through spray drying. They chose the diuretic mannitol as a soluble carrier for the calcium phos- phate nanoparticles. A key conclusion of the study was that mannitol protected the size of the released nanoparticles. In addition, increasing the mannitol concentration versus the calcium phosphate amount caused an increase in microparticle respirability, i.e., its ability to be breathed in. “These quality attributes are crucial for the use of mic- roparticles embedding nanoparticles for targeting the lung first and then the heart,” the researchers conclude. The 2018 paper, published in Science Translational Medicine, is “Inhalation of peptide-loaded nanoparticles improves heart Scanning electron plan-view micrographs of doughnut-shaped mic- roparticles with a calcium phosphate:mannitol ratio of 14:1. failure” (DOI: 10.1126/scitranslmed.aan6205). The 2021 open-access paper, published in Pharmaceutics, is “Inhalable microparticles embedding calcium phosphate nanoparticles for heart targeting: The formulation experimen- tal design” (DOI: 10.3390/pharmaceutics13111825). n American Ceramic Society Bulletin, Vol. 101, No. 2 | www.ceramics.org 21 Credit: Quarta et al., Pharmaceutics (CC BY 4.0)PDF Image | hydrogen as an alternative fuel
PDF Search Title:
hydrogen as an alternative fuelOriginal File Name Searched:
March2022.pdfDIY PDF Search: Google It | Yahoo | Bing
CO2 Organic Rankine Cycle Experimenter Platform The supercritical CO2 phase change system is both a heat pump and organic rankine cycle which can be used for those purposes and as a supercritical extractor for advanced subcritical and supercritical extraction technology. Uses include producing nanoparticles, precious metal CO2 extraction, lithium battery recycling, and other applications... More Info
Heat Pumps CO2 ORC Heat Pump System Platform More Info
| CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com | RSS | AMP |