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Karthikeyan et al. Nanocurcumin: A Promising Candidate for Therapeutic Applications specific and in this sense, they are just delivered onto the healthy tissues found around the tumor or cancer cells. So, larger attention may be focused on the development of nanodrug delivery systems that could be tissue-specific. Hybrid nanoparticles (comprised of two or more components comprised each other enveloped curcumin) developed for a specific cell targeting. These hybrid nanoparticles exhibit potent cytotoxicity in cancerous cells compared with nanoparticles and free curcumin. However, further human considerations are required to evaluate the efficacy and toxicity of hybrid nanoparticles with clinical trials. It is also worth investigating that whether curcumin can be used as a drug alone or in a suitable formulation with an additional drug, which could enhance its potential for the frontiers of chemotherapeutic strategies is yet to be addressed. In this view, curcumin-loaded nanoparticles should be incorporated into any other therapeutic treatment to reduce the amount of the main drug which can give the outcome of improved therapeutic activities with less toxicity. As a result, it can improve the therapeutic efficacy of curcumin-loaded nanoparticles along with less toxicity. Although, researchers should give priority to expanding the industrial production of nano-encapsulated curcumin. For this reason, discovering cost- REFERENCES Abrahams, S., Haylett, W. L., Johnson, G., Carr, J. A., and Bardien, S. (2019). Antioxidant Effects of Curcumin in Models of Neurodegeneration, Ageing, Oxidative and nitrosative Stress: A Review. Neuroscience 406, 1–21. doi: 10.1016/j.neuroscience.2019.02.020 Abruzzo, A., Zuccheri, G., Belluti, F., Provenzano, S., Verardi, L., Bigucci, F., et al. (2016). Chitosan nanoparticles for lipophilic anticancer drug delivery: development, characterization and in vitro studies on HT29 cancer cells. 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Neurotherapeutics 15, 430–438. doi: 10.1007/s13311-018-0606-7 Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., et al. (2013). Liposome: classification, preparation, and applications. Nanoscale Res. Lett. 8, 102. doi: 10.1186/1556-276X-8-102 effective techniques to nanoencapsulate curcumin is an industrial requirement for decreasing manufacture prices and open outstanding competition with synthetic additives and drugs. Finally, the application of nanocurcumin is still in its initial phases. Its progress requires serious and committed efforts through a system of organized and scheduled trials based entirely on the goal of enhancing curcumin’s beneficial effects. AUTHOR CONTRIBUTIONS AK built the layout of the article, collected literature, and wrote the article. TM and NS provided suggestions in manuscript writing. AK and TM edited it. 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Macromol. 104, 1012–1019. doi: 10.1016/ j.ijbiomac.2017.06.096 Frontiers in Pharmacology | www.frontiersin.org 17 May 2020 | Volume 11 | Article 487PDF Image | Nanocurcumin Promising Candidate for Therapeutic Applications
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