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J. Funct. Biomater. 2022, 13, 27 20 of 36 Figure 11. 2DNMs as a unique platform for drug loading and delivery. LC and EE of: (a) DOX; (b) ICG; (c) DOX&ICG onto MLDH nanosheets with various mass ratios; (d) LC of DOX&ICG onto MLDH nanosheets with various mass ratios of DOX:IC; (e) adsorption curves of DOX, ICG, and DOX&ICG onto MLDH nanosheets (Reprinted with permission from ref. [112]. 2018, Wiley VCH). As another example of 2DNMs, TMDs have shown to be a promising 2D drug deliv- ery platform for efficient cancer treatment. In this regard, MoS2 nanosheets as the most typical form of TMDs in nano-based drug delivery systems have attracted much attention. Yin and his co-workers demonstrated the possibility of efficient chemotherapy via appli- cation of functionalized MoS2 nanosheets with chitosan (CS) as drug nanocarriers [105]. CS-decorated MoS2 nanosheets were prepared by a modified intercalation-exfoliation pro- cedure, followed by chitosan decoration to enhance the biocompatibility and physiologi- cal stability of these nanosheets. In this research, these MoS2-CS nanosheets met the re- quirements of exploitation for a NIR light-triggered drug delivery system because of strong NIR photothermal absorbance. Furthermore, the 2D planar topology of these nanostructures empowers them to access high antitumor drug (i.e., DOX) loading capac- ity. Results of this study also indicate favorable efficiency of DOX release of MoS2-CS- DOX undergone 808 nm NIR laser irradiation on account of the photothermal effect (Fig- ure 12).PDF Image | Nanomaterials beyond Graphene for Biomedical Applications
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