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electronic watch in a wearable manner. A hybridized self-charging power textile was also demonstrated by integrating fiber-shaped TENG, solar cells and supercapacitors together.136 3.2 Self-Powered Iontophoretic Transdermal Drug Delivery System Driven and Regulated by Biomechanical Motions Transdermal drug delivery (TDD), which refers to the transport of pharmacological agents through the skin, has become a common medical practice with over twenty commercially available transdermal drugs approved by the Food and Drug Administration (FDA).137-139 Compared to other alternatives like oral delivery and hypodermic injection, TDD has many advantages such as non-invasive, painless, convenient, inexpensive and self-administered. It avoids the risk of disease transmission by needle re-use and the first- pass hepatic metabolism of drugs. It enables on-demand administration of drugs at targeted skin sites, making it attractive for long-term treatment without the risk of high-level spikes of therapeutics in the systemic circulation.140 The availability of drugs that can be delivered via TDD systems have been extended by various methods of enhancing skin permeability, including the use of chemical molecules, biomolecules and physical tools.138 Iontophoresis has proven to be an effective physical permeation enhancement approach for TDD to deliver hydrophilic and/or charged molecules across the skin.141-143 An electric current (typically < 0.5 mA/cm2) is applied to the skin to drive the flow of charged molecules, while the resulted electroosmotic flow of biofluids transports the charge-neutral molecules.138 Although iontophoretic TDD systems has been commercialized for local dermal analgesia, the application of such electrically controlled 78PDF Image | HIGH PERFORMANCE TRIBOELECTRIC NANOGENERATOR AND ITS APPLICATIONS
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