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successfully delivered to the inner tissue with the assist of TENG. Cross-sectional images were then taken to further compare the results. The distinct contrast between the fluorescent cross-sectional images (Figure 32g and Figure 32k) presented strong evidence that more R6G was released into the pigskin from the TENG-driven experiment and the R6G was delivered to the deeper tissue with TENG. Therefore, the results here successfully proved the feasibility of the proposed self-powered iontophoretic TDD system driven by biomechanical motions, through the integration of a wearable TENG and an electrically- assisted drug patch. It is worth mentioning that this system can achieve TDD in a non- invasive manner, as opposed to the systems previously reported. In summary, a self-powered, non-invasive TDD system consisting of a wearable TENG and an iontophoretic patch has been proposed. The emerging TENG technology offers a facile and cost-effective solution for wearable energy harvesters that can detect body motions and convert associated biomechanical energy into electricity simultaneously, while the rationally designed hydrogel-based drug patch enables TDD in a non-invasive and imperceptible manner. The feasibility of the proposed system was successfully demonstrated on pigskins using dyes as the simulated drugs, with both bright-field and fluorescent images indicating that the TENG outputs assisted the drug release process. Depending on the application scenario where the triggering motion of TENG is either involutory or intentional, furthermore, both sustained drug release and intentional release with feedback control can be achieved. This work provides a promising solution for non- invasive, electrically-assisted TDD with closed-loop sensation and therapy, and promotes TENG-based self-powered systems towards advanced biomedical treatment in the era of IoT. 89PDF Image | HIGH PERFORMANCE TRIBOELECTRIC NANOGENERATOR AND ITS APPLICATIONS
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