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CHAPTER 3. COST IMPACTS OF LEU-TARGET CONVERSION 50 MARKET IMPACTS OF CONVERTING TO LOW-ENRICHED URANIUM TARGETS FOR MEDICAL ISOTOPE PRODUCTION, ISBN 978-92-64-99197-2, © OECD 2012 While countries may have differing views on the various options, given their own economic, regulatory, or political situation, the paper provides a brief review of the options from the starting point of the HLG-MR policy approach to achieving a long-term reliable supply of 99Mo/99mTc. 3.5. Conclusions regarding the expected cost impacts from LEU-target conversion From the modelling undertaken to assess the cost impacts from converting to using LEU targets, it is clear that conversion will result in increased costs for the supply chain. LEU-based 99Mo, given the increased capital and operating costs, including the impact from reduced production, is expected to be more expensive than HEU-based 99Mo from the same or a similar facility. However, the overall move to full-cost recovery, coupled with the need for new irradiation and related processing infrastructure, should have a larger price impact on the market than the move to converting existing facilities to use LEU targets. The impact on the end user is expected to be very small, increasing the radiopharmacy dose by less than 8% and having less than a 0.4% impact on the final overall procedure costs. However, this small impact is very important upstream, where total cost of LEU-target conversion could be close to EUR 100 million for the whole supply chain. Given the externality nature of the decision for 99Mo irradiators and processors to convert to using LEU targets, and the costs imposed on the market without any specific benefits for end users, there may be a role for governments to encourage non-HEU-based production and consumer uptake.PDF Image | Market Impacts of Converting to Low-enriched Uranium Targets for Medical Isotope Production
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