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US 2005/0142231A1 Jun.30,2005 afterreaction.LCAT activity(esteri?cationofcholesterol: nmol/ml serum/h) can be calculated by the following for mula: LCA T activity: FC(OD)beforereaction-FC(OD)afterreaction 0O5 107 2 0.138><386 X ' X X? [0024] Result:Compoundproductscanenhancetheactiv ityofLCAT greatlyatthedoserateof3.0g/kgand6.0g/kg Whereas the action of atromid-s Was not noticeable (Table 3) TABLE 3 EffectofcompoundproductsupontheactivityofLCAT (_1SD) kg Water Were added to every 100 kg of the ?ve-plant raW materials, extracted at 100° C. respectively for 3, 2 and 1 hours. The ?ltrate extracted by Water Was blended, concen trated at 100° C. and left to stand at room temperature for six hours. The supernatant Was discarded. The concentrate Was absorbedWithWLD resinthroughacolumn?lledWith WLD resin.ThecomponentsabsorbedonWLD resinWas eluted With 65% ethanol. After recovery of ethanol, itWas blended With the recti?ed reserve and spray dried at 85° C. Finally a quantitative analysis by ?ngerprinting Was made Withhighperformanceliquidchromatography. [0027] 3.Thepharmacologicalactivityexperimentonthe effect of the ?ve-plant compound hypolipemic products to reduce total cholesterol in serum of rabbit shoWs that the compound products can greatly inhibit the rise in serum cholesterol of rabbit fed With cholesterol. The pharmaco logical activity experiment on the effect upon the activity of lecithin cholesterol acyltransferase in rats suffering from hyperlipemiashoWsthecompoundproducts,comparedWith the high lipid group, can greatly reduce the serum choles trole content and also loWer serum triglyceride content. Therefore, they are effective against atherosclerosis. 1.NoW Ideclarethepharmacologicalactivityandmanu facturing process of the ?ve-plant compound hypolipemic products—RhiZomaAlismatis,RhiZomaOurcumaeLongae, Herba Gynostemmae, Fructus Ligustri Lucidi and Herba Epimedii as my invention. I think my invention includes the products made by extracting the ?ve-plant compound raW materials With liquidCO2?rst,isolatingandrectifyingforreserve. Then the ?ve-plant raW materials Were extracted With Waterorethanol,absorbedWithWLD resin,elutedand dried together With the recti?ed reserve. Finally, a quantitative analysis Was made. Ithinkinmy invention,the?ve-plantcompound hypo lipemic products have the pharmacological action to inhibit the rise in serum cholesterol in rabbit, enhance LCAT activity and reduce the content of serum cho lesterol and triglyceride clinically they can be used in the treatment of atherosclerosis and obesity. * * * * * Group Normal Compound products Compound products Astromid-s Model Number Dose ofanimal(n) (g/kg) LCAT activity (TC esteri?cation nmol/ml/h) 109 r 7.6 628 r 192 837 r 184 536 r 277 415 r 166 Pvalue <0.05 <0.01 >0.05 10 10 10 10 10 — 3.0 6.0 0.13 — DETAILED DESCRIPTION OF THE INVENTION [0025] 1.Thepharmacologicalactivityandmanufacturing process of the ?ve-plant compound hypolipernic products belong to the combined patent on the pharmacological activity of natural products and methods of isolating and purifying the same. The ?ve-plant compound products are composed of 25% RhiZoma Alismatis, 16.67% RhiZoma Ourcumae Longae, 20.83% Herba Gyostemmae, 20.83% Fructus Ligustri Lucidi and 16.67% Herba Epimedii. [0026] 2.ThestandardproductsWeremadebyextracting the ?ve-plant raW materials With supercritical ?uid CO2, isolating the gaseous CO2 and plant components and recti fying the same for future use. Then 300 kg, 200 kg and 100PDF Image | PHARMACEUTICAL ACTIVITY AND MANUFACTURING METHOD
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