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$300,000, mentorship and access to GE researchers and industry thought leaders. In 2015, they would have an opportunity to win an additional $500,000 award. “The first award allowed us to immediately begin research to identify biomarkers of injury occurring in the brains of athletes or military personnel,” Patel says. Their aim was to collect blood samples from people who had suffered from a traumatic brain injury. When they were looking for test subjects, one of the partnerships they formed was with UM Head Athletic Trainer J.C. Weida. “That initial study was predominately with UM athletes,” Patel says. traumatic encephalopathy, or CTE. Recent findings show people who suffer numerous brain injuries or get a second TBI before they are fully healed from the first experience long-term effects on the brain. Rau and Patel decided they would expand their study to see if the biomarkers could be observed in people who suffered from CTE as an end-stage disease. They formed a partnership with the brain bank at Boston University and obtained tissue samples. They were pleased to find the familiar markers from their previous studies also observed in the postmortem human tissue. research team to clinically validate the research – both in TBI and in CTE. Because proteins work in the body as transporters and catalysts, a disruption in one area could cause further-reaching problems. The research may help solve the mystery of why a localized brain injury causes damage throughout the entire brain. “The workday never ends, but that’s OK, because we are chasing down a dream,” Rau says. Part of that dream is to create diagnostic tools that will directly benefit TBI patients. In August 2015, the research team earned $2 million in follow-up funding from the state During their annual physicals, Weida alerted all football and soccer players of the opportunity to be involved in the study. Those who elected to participate had their blood drawn. Then if the athlete suffered a concussion, they could choose to have their blood drawn within 48 hours of the injury. The researchers collected and examined the samples, looking for the biomarkers to show up in the blood. Researchers Alex Santos, Tom Rau and Sarj Patel (standing left to right) test the extent of brain injuries using equipment that tracks the eye movements of subjects. Agnew was one of the players who agreed to participate. “We just want to help out,” Agnew says. “We know what a unique opportunity it is to have this kind of research [at UM].” The researchers got to work comparing the biomarkers in the control sample to the biomarkers in the blood of TBI sufferers. Some of these markers mirrored the patterns they observed in the animal model. The researchers were encouraged, but they wanted to know more. The topic of brain injuries has become a high-profile issue highlighted by a large number of former NFL players, among others, being diagnosed with a neurodegenerative disease called chronic “We gave [GE/NFL] twice as much data as we originally promised,” Rau says. “It was a hard year, but we knew we had one shot at it, and we wanted to dazzle them.” NFL and GE were impressed. “The fact that we were seeing very similar changes in the markers really pushed home that story for them,” Patel says. At the end of July, Rau and Patel received a phone call informing them they had been selected for the final round of funding. The small UM team was among six other final winners nationally selected from the initial group of 16 to receive a second-round, $500,000 grant. The current award will allow the Vision 2016 18 and the Montana University System. Using their GE/NFL findings as a launch-point, the team will collaborate with other TBI researchers and private companies to make their dream a reality. “We want our research to improve health, create jobs and generate revenue for Montana,” Rau says. “We’ve got to get it right since we are one of the first,” Patel says. V For more information email sarjubhai. patel@umontana.edu or thomas.rau@ mso.umt.edu.PDF Image | Carbon Vision 2016
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