PDF Publication Title:
Text from PDF Page: 009
Nanomaterials 2018, 8, 681 9 of 25 Moreover, the beneficial addition of antimicrobial AgNPs within composite matrices designed for bone-tissue engineering were emphasized. In a recent study, it was shown that AgNPs could promote the osteogenesis and proliferation of mesenchymal stem cells (MSCs), in order to enhance the healing process of bone fracture [212]. A correlation was also reported between NP uptake and growth in clathrin-dependent endocytosis in the case of MSCs and osteoblasts, indicating that this route may represent the principal cellular internalization pathway of AgNPs [213]. Taking into account the limited capacity of bone tissue to fully reconstruct or replace severe defects, the development of novel and performance-enhanced implants is required. Thus, new pathways were used to stimulate bone regeneration and also to prevent the side effects correlated with therapeutics currently used in the clinic [214]. 8. Silver Nanoparticles for Other Medical Applications Thanks to their unique physiochemical properties and biofunctional features, such as anti-inflammatory, anti-angiogenesis, antiplatelet, antiviral, antifungal, and antibacterial activities, AgNPs play an important role in the development and implementation of novel biomedicinal strategies [45]. Recently, AgNPs were intimately investigated regarding their promising anticancer effects exhibited in different human cancerous cell lines, such as endothelial cells, IMR-90 lung fibroblasts, U251 glioblastoma cells, and MDA-MB-231 breast cancer cells [215,216]. AgNPs possess the intrinsic capability to merge with mammalian cells and to easily penetrate them by means of energy-driven internalization pathways [217]. Another attractive property of AgNPs relies on their specific fluorescence, making them suitable candidates for detection and dose-enhancement purposes in X-ray irradiation applications [218]. At the moment, the combination of therapy and diagnosis, known as theranostics, represents the most important, attractive, and challenging approach embraced by healthcare practitioners and researchers with respect to the effective and personalized therapy of cancer desideratum [219]. AgNPs are also plasmonic structures, capable of particularly scattering and absorbing the light impinging certain areas. After their selective uptake into cancerous cells, AgNP-derived scattered light can be used for imaging purposes, whereas absorbed light can be used for selective hyperthermia [220]. Cardiovascular diseases (CVDs) represent a major cause of worldwide human death, being responsible for more than 17.7 million deaths in 2015 [221]. Recently, many studies focused on the evaluation of the effects of AgNPs on various types of cell encountered in the complex vascular system, but the reported results were contradictory. However, the collected data can provide substantial knowledge with respect to the potential benefits of AgNPs for pathological and physiological stages related to the cardiovascular system, thus contributing to the development of novel and specific molecular therapies in vascular tone, vasopermeability, and angiogenesis [222]. Cardiovascular pathologies, such as hypertension, may influence the toxic effects induced by AgNPs [223]. The first silver-modified cardiovascular medical device was a prosthetic silicone heart valve coated with elemental silver, which was developed to avoid valve-related bacterial infection and to reduce inflammation response [224]. Malaria, one of the most common infectious diseases encountered in tropical and sub-tropical regions, became a major healthcare concern all around the world. It was shown that AgNPs possess powerful activity against both the malarial parasite (Plasmodium falciparum) and its related vector (Anopheles female mosquito). The intrinsic anti-plasmodial effects exhibited by nanosilver-based compounds and materials represent a solid starting point toward the nanotechnology-derived therapy and worldwide control of malaria [24,225,226]. The human eye is a complex organ, with impressive vascularization and innervation, that can be easily exposed to microbial contamination under proper temperature and humidity conditions [227,228]. Nanosilver-based compounds and materials proved promising potential toward the development of unconventional and performance-enhanced therapy of eye-related infectious conditions. AgNPs coated with calcium indicators proved to have reduced damage with respect toPDF Image | Biomedical Applications of Silver Nanoparticles
PDF Search Title:
Biomedical Applications of Silver NanoparticlesOriginal File Name Searched:
nanomaterials-08-00681-v2.pdfDIY PDF Search: Google It | Yahoo | Bing
Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info
Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info
All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info
CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info
Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info
Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info
Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.
Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.
CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com (Standard Web Page)