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Nanomaterials 2018, 8, 681 12 of 25 The current limitations related to conventional healthcare practice and the latest challenges resulting from nanosilver-based technology outline the impressive potential of silver nanoparticles in biomedicinal applications. Whether we consider the modification of available biomaterials and devices or the development of novel nanostructured ones, AgNPs are ideal candidates for achieving the very close modern biomedicine desideratum. Author Contributions: A.-C.B., O.G., A.M.G., L.M., A.F., and E.A. designed and wrote the paper. Acknowledgments: This work was supported by a grant from the Romanian National Authority for Scientific Research and Innovation, UEFISCDI, project number 45PCCDI/2018-Nanostructuri bioactive pentru strategii terapeutice inovatoare. Conflicts of Interest: The authors declare no conflict of interest. References 1. Abou El-Nour, K.M.M.; Eftaiha, A.; Al-Warthan, A.; Ammar, R.A.A. Synthesis and applications of silver nanoparticles. Arab. J. Chem. 2010, 3, 135–140. [CrossRef] 2. Faisal, N.; Kumar, K. Polymer and metal nanocomposites in biomedical applications. Biointerface Res. Appl. Chem. 2017, 7, 2286–2294. 3. Alexander, J.W. History of the medical use of silver. Surg. Infect. 2009, 10, 289–292. [CrossRef] [PubMed] 4. Ioan-Avram, N.; Anton, F.; Maria, S.; Denisa, F.; Ovidiu, O.; Ecaterina, A. Silver based materials for biomedical applications. Curr. Org. Chem. 2014, 18, 173–184. 5. Geraldo, D.A.; Needham, P.; Chandia, N.; Arratia-Perez, R.; Mora, G.C.; Villagra, N.A. Green synthesis of polysaccharides-based gold and silver nanoparticles and their promissory biological activity. Biointerface Res. Appl. Chem. 2016, 6, 1263–1271. 6. Chowdhury, N.R.; MacGregor-Ramiasa, M.; Zilm, P.; Majewski, P.; Vasilev, K. ‘Chocolate’ silver nanoparticles: Synthesis, antibacterial activity and cytotoxicity. J. Colloid Interface Sci. 2016, 482, 151–158. [CrossRef] [PubMed] 7. Tavaf, Z.; Tabatabaei, M.; Khalafi-Nezhad, A.; Panahi, F. Evaluation of antibacterial, antibofilm and antioxidant activities of synthesized silver nanoparticles (AgNPs) and casein peptide fragments against streptococcus mutans. Eur. J. Integr. Med. 2017, 12, 163–171. [CrossRef] 8. Domeradzka-Gajda, K.; Nocun, M.; Roszak, J.; Janasik, B.; Quarles, C.D., Jr.; Wasowicz, W.; Grobelny, J.; Tomaszewska, E.; Celichowski, G.; Ranoszek-Soliwoda, K.; et al. A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminum chloride, methyl paraben or di-n-butyl phthalate. Toxicol. Lett. 2017, 272, 38–48. [CrossRef] [PubMed] 9. Kraeling, M.E.K.; Topping, V.D.; Keltner, Z.M.; Belgrave, K.R.; Bailey, K.D.; Gao, X.; Yourick, J.J. In vitro percutaneous penetration of silver nanoparticles in pig and human skin. Regul. Toxicol. Pharm. 2018, 95, 314–322. [CrossRef] [PubMed] 10. Fortunati, E.; Peltzer, M.; Armentano, I.; Jiménez, A.; Kenny, J.M. Combined effects of cellulose nanocrystals and silver nanoparticles on the barrier and migration properties of pla nano-biocomposites. J. Food Eng. 2013, 118, 117–124. [CrossRef] 11. Kumar, S.; Shukla, A.; Baul, P.P.; Mitra, A.; Halder, D. Biodegradable hybrid nanocomposites of chitosan/gelatin and silver nanoparticles for active food packaging applications. Food Packag. Shelf 2018, 16, 178–184. [CrossRef] 12. Pannerselvam, B.; Dharmalingam Jothinathan, M.K.; Rajenderan, M.; Perumal, P.; Pudupalayam Thangavelu, K.; Kim, H.J.; Singh, V.; Rangarajulu, S.K. An in vitro study on the burn wound healing activity of cotton fabrics incorporated with phytosynthesized silver nanoparticles in male Wistar albino rats. Eur. J. Pharm. Sci. 2017, 100, 187–196. [CrossRef] [PubMed] 13. Zhou, Y.; Tang, R.C. Facile and eco-friendly fabrication of agnps coated silk for antibacterial and antioxidant textiles using honeysuckle extract. J. Photochem. Photobiol. B 2018, 178, 463–471. [CrossRef] [PubMed] 14. Kejlová, K.; Kašpárková, V.; Krsek, D.; Jírová, D.; Kolárˇová, H.; Dvorˇáková, M.; Tománková, K.; Mikulcová, V. Characteristics of silver nanoparticles in vehicles for biological applications. Int. J. Pharm. 2015, 496, 878–885. [CrossRef] [PubMed]PDF Image | Biomedical Applications of Silver Nanoparticles
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