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Hydrogel Forming Dressings Containing Silver Nanoparticles

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Hydrogel Forming Dressings Containing Silver Nanoparticles ( hydrogel-forming-dressings-containing-silver-nanoparticles )

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Nanomaterials 2021, 11, 96 Nanomaterials 2021, 11, x FOR PEER REVIEW Nanomaterials 2021, 11, x FOR PEER REVIEW Figure 1. Cross-linking of poly(vinyl alcohol) (PVA) with silver nitrate under hydrothermal conditions. Figure 1. Cross-linking of poly(vinyl alcohol) (PVA) with silver nitrate under hydrothermall condiittiions.. Figure 1. Cross-linking of poly(vinyl alcohol) (PVA) with silver nitrate under hydrothermal conditions. 6 of 19 6 of 20 6 of 20 Figure 2. Silver cross-linked PVA films containing 1%, 3% or 5% w/w silver nitrate, dried at 60 °C overnight and then heat cured at various temperatures for 90 min. The appearance of the same films after immersion in water and constant agitation for one week at 37 °C in an incubator shaker is shown in Figure 3. The films that had only been dried and the films dried and heat cured at 80 °C for 90 min dissolved rapidly in water; however, the films heat cured at 110 °C for 90 min were only partly dissolved after Figure 2. Silver cross-linked PVA films containing 1%, 3% or 5% w/w silver nitrate, dried at 60 °C Foingeurwe e2e. kSilavnerdctrhoses-flilnmkesdhPeVatAcfuilrmesdcaotnt1a4in0i°nCg 1f%or, 39%0 omr i5n%awpp/weasrilevdertnoitreamte,adinrieidntatc6t.0 T°◦Che Figure 2. Silver cross-linked PVA films containing 1%, 3% or 5% w/w silver nitrate, dried at 60 C overnight and then heat cured at various temperatures for 90 min. aovqeurenoiguhst laenadchthaeten fhreoamt cuthredfialtmvsartioouks toenmapeyreatlulorwes fcorlo90urm, iwn.hich was particularly noticea- overnight and then heat cured at various temperatures for 90 min. ble for the films that showed some degree of dissolution in water. The appearance of the same films after immersion in water and constant agitation for The appearance of the same films after immersion in water and constant agitation for one week at 37 °C in an incubator shaker is shown in Figure 3. The films that had only one week at 37 °C in an incubator shaker is shown in Figure 3. The films that had only been dried and the films dried and heat cured at 80 °C for 90 min dissolved rapidly in been dried and the films dried and heat cured at 80 °C for 90 min dissolved rapidly in water; however, the films heat cured at 110 °C for 90 min were only partly dissolved after water; however, the films heat cured at 110 °C for 90 min were only partly dissolved after one week and the films heat cured at 140 °C for 90 min appeared to remain intact. The one week and the films heat cured at 140 °C for 90 min appeared to remain intact. The aqueous leachate from the films took on a yellow colour, which was particularly noticea- aqueous leachate from the films took on a yellow colour, which was particularly noticea- ble for the films that showed some degree of dissolution in water. ble for the films that showed some degree of dissolution in water. Figure 3. The same films as shown in Figure 2 after seven days’ incubation in water at 37 °◦C with Figure 3. The same films as shown in Figure 2 after seven days’ incubation in water at 37 C with constant agitation at 70 rpm. constant agitation at 70 rpm. The observed change in the color of PVA films containing silver nitrate is consistent with the reduction of silver ions to silver metal nanoparticles. In essence, PVA has a number Figure 3. The same films as shown in Figure 2 after seven days’ incubation in water at 37 °C with Figure 3. The same films as shown in Figure 2 after seven days’ incubation in water at 37 °C with constant agitation at 70 rpm. constant agitation at 70 rpm.

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