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Hydrogel Forming Dressings Containing Silver Nanoparticles

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Hydrogel Forming Dressings Containing Silver Nanoparticles ( hydrogel-forming-dressings-containing-silver-nanoparticles )

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Nanomaterials 2021, 11, x FOR PEER REVIEW 12 of 20 Nanomaterials 2021, 11, 96 12 of 19 up to two weeks. As demonstrated, the quantity of silver released in the initial phase de- with increasing concentration of silver in the film. For example, after five days the percent creased with increasing concentration of silver in the film. For example, after five days the silver released from films containing 1%, 3% or 5% w/w silver nitrate was 43, 22 and 17.5% percent silver released from films containing 1%, 3% or 5% w/w silver nitrate was 43, 22 respectively. Between nine and 14 days, the rate of silver release from each of the three and 17.5% respectively. Between nine and 14 days, the rate of silver release from each of film types was roughly equal and, after 28 days, release of silver had leveled out at 69%, the three film types was roughly equal and, after 28 days, release of silver had leveled out 41.5% and 31.8% respectively. These findings are consistent with visual observations in at 69%, 41.5% and 31.8% respectively. These findings are consistent with visual observa- that films with 1% and 3% w/w silver nitrate exhibit rapid, partial or full dissolution when tions in that films with 1% and 3% w/w silver nitrate exhibit rapid, partial or full dissolu- immersed in water. When 5% w/w silver nitrate is present, PVA films remain largely intact tion when immersed in water. When 5% w/w silver nitrate is present, PVA films remain and, although a certain percentage of each film does dissolve in water, the burst release largely intact and, although a certain percentage of each film does dissolve in water, the phase of silver ions or nanoparticles is modulated. burst release phase of silver ions or nanoparticles is modulated. 80 70 60 50 40 30 20 10 0 0 5 10 15 20 25 30 Time (days) 1% silver nitrate 3% silver nitrate 5% silver nitrate Figure 6. In vitro release of silver from PVA/silver nitrate films heated at 140 °C for 90 m and then immersed in water as Figure 6. In vitro release of silver from PVA/silver nitrate films heated at 140 ◦C for 90 m and then immersed in water as a a function of silver content. function of silver content. Silver release (%)

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