PDF Publication Title:
Text from PDF Page: 014
polysaccharides) and synthetic polymers. 3.5.1. PLA/PLGA Polylactic acid (PLA) and polylactic acid-glycolic acid copolymer (PLGA) (Figure 6) have been widely used in drug delivery systems, due to their excellent biocompatibility, biodegradability and Molecules 2020, 25, 4613 14 of 36 particle size control [211,212]. Figure 6.. Schematic representation of the designed targeted EGCG NPs. Chemiicall structure of (-)- epigallocatechin-3-gallate (EGCG), the PEGylated PLGA polymers (PLGA-PEG), and the targeting ligands DCL and AG. Adapted from refference[[213]].. The use of PLA/PLGA nanoparticles improves the water solubility and poor stability of polyphenols. The release kinetics of polyphenol-PLA/PLGA nanoparticles in vitro show rapid release are at first followed by slow release, which demonstrates the controlled release of polyphenol compounds from PLA/PLGA nanoparticles [214]. Similar to other nanoparticles, PLA/PLGA also enhances the functional activity of polyphenols, such as anti-inflammatory, antioxidant and anti-cancer properties [215–217]. Although PLA has many advantages, it has certain limitations as a drug delivery system due to its hydrophobicity and low chemical stability. These limitations are particularly obvious when used for oral administration, because the nanopariticles are very likely to be intercepted and quickly cleared by mucus and cilia [218]. To avoid these limitations, PLA/PLGA nanoparticles are often modified by other polymers (such as polyethylene glycol (PEG) or chitosan) or are used in combination with other polymers. Studies have shown that a PEG coating on the nanoparticle surface can ensure rapid passage through the mucus layer, and significantly improve hydrophilicity and stability [219]. The toxicity of resveratrol-loaded PEG-PLA polymer nanoparticles to CT26 colon cancer cells was the same as that of free resveratrol, but encapsulation significantly increased its stability and cycling time, conferring significant anti-tumor effects [220]. Mixed micelles prepared from mPEG-PLA/TPGS enhanced the absorption of curcumin from the gastrointestinal tract, and its oral availability was much higher compared to curcumin suspension [221]. New targeted nanoparticles coated with EGCG exhibited excellent anti-proliferative activity in vitro, and tumor inhibition by the nanoparticles was significantly enhanced compared with the natural compounds [222]. In addition to PEG modification of PLGA, other polymers such as chitosan are often used as modifiers to increase the stability of nanoparticles. Chitosan oleic acid was applied to PLGA containing curcumin by emulsification and solvent evaporation, resulting in PLGA nanoparticles that were more stable than polymer micellar ones [223]. 3.5.2. Chitosan Chitosan is a semi-synthetic polysaccharide obtained by the deacetylation of chitin, which is widely present in nature, and is the only alkaline polysaccharide. Chitosan has received increasing attention, due to its good biocompatibility, degradability, non-antigenicity, high permeability, non-toxicity and good film-forming properties [224,225]. In addition, it has adhesive properties, and can reversibly open the tight junctions between epithelial cells, thereby promoting paracellular transport betweenPDF Image | Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols
PDF Search Title:
Nanoformulations to Enhance the Bioavailability and Physiological Functions of PolyphenolsOriginal File Name Searched:
molecules-25-04613-v2.pdfDIY PDF Search: Google It | Yahoo | Bing
Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info
Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info
All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info
CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info
Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info
Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info
Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.
Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.
| CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com | RSS | AMP |