PDF Publication Title:
Text from PDF Page: 012
articles Jain et al. Figure 12. SNP containing formulation (S-gel) and its antimicrobial activity. S-gel with SNP concentration of 0.02 mg/g (i) and 0.1 mg/g (ii) and typical packaged product (iii). Zones of inhibition shown by 1% silver sulfadiazine (a), control gel without SNP (b) and S-gel with SNP concentration of 0.02 mg/g (c) and 0.1 mg/g (d). Table 6. Sensitivity Zones of Topical Antibacterial Agents against Standard Bacterial Cultures and MDR Clinical Isolates zone diameter (zone size in mm*) S-gel 6-8 h for killing most bacterial strains (please see data on MBC) but the concentration of silver released is very low (below the detection limit of a sensitive atomic absorption spectrophotometersunpublished data). The rationale of the FICI study considered two possibili- ties, viz., (a) adverse effect on the antimicrobial action of SNP in the presence of commonly used antibiotics and (b) beneficial effect of certain antibiotics in combination with SNP to provide enhanced and broad spectrum antimicrobial to handle infections of mixed etiology. Our results showed an antagonistic effect of SNP-chloramphenicol combination. On the other hand, additive and synergistic effects were seen for SNP combinations with streptomycin, kanamycin, poly- myxin B sulfate, ampiclox and ceftazidime. These results suggest that, in the future, such combinations could be developed for getting more effective formulations. Combined antimicrobial activity of silver-water dispersion (colloidal silver) and antibiotics against seven bacterial strains was studied by de Souza et al.25 and reported synergistic combination with amikacin and cefoperazone. The post agent effect (PAE) is an important pharmaco- dynamic parameter investigated during the development of an antimicrobial agent. It contributes to the choice of antimicrobial dosing regimens and is defined as length of time that bacterial growth is suppressed following brief exposure to the antimicrobial agent. Generally, the PAE (25) de Souza, A.; Mehta, D.; Leavitt, R. W. Bactericidal activity of combinations of Silver-Water Dispersion with 19 antibiotics against seven microbial strains. Curr. Sci. 2006, 91, 926–929. 1% silver 0.02 mg/g 0.1 mg/g sulfadiazine organism tested E. coli ATCC 117 3 5 6 P. aeruginosa ATCC 9027 10 13 13 S. aureus ATCC 6538 5 6 9 B. subtilis ATCC 6633 6 8 12 P. vulgaris NCIB 4157 5 8 12 S. abony NCTC 6017 3 6 8 S. typhimurium ATCC 23564 5 9 13 K. aerogenes ATCC 1950 9 9 13 S. epidermidis ATCC 12228 4 6 8 Pseudomonas sp. # 1 MDR 10 13 13 Staphylocococcus sp. # 1 MDR 4 6 8 * Corrected zone of inhibition ) (diameter of inhibited area - diameter of well). the concentration of silver released from Acticoat is normally in the range of 60-80 μg/mL,24 which helps achieve killing of the organisms within 30 min. In comparison, SNP require (23) (24) Yin, H. Q.; Langford, R.; Burrell, R. E. Comparative evaluation of the antimicrobial activity of ActicoatTM antimicrobial barrier dressing. J. Burn Care Rehab. 1999, 20, 195–200. Wright, J. B.; Hansen, D. L.; Burrell, R. E. The comparative efficacy of two antimicrobial barrier dressings. Wounds 1998, l0, 179–188. 1398 MOLECULAR PHARMACEUTICS VOL. 6, NO. 5PDF Image | Silver Nanoparticles in Therapeutics: Antimicrobial Gel
PDF Search Title:
Silver Nanoparticles in Therapeutics: Antimicrobial GelOriginal File Name Searched:
SilverNanoparticlesinTherapeutics-TopicalUse.pdfDIY PDF Search: Google It | Yahoo | Bing
Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info
Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info
All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info
CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info
Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info
Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info
Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.
Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.
CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com (Standard Web Page)