PDF Publication Title:
Text from PDF Page: 015
SilVer Nanoparticle Based Formulation for Topical Use articles Wong et al.49 Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, the authors showed that silver nanoparticles exerted positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenetic cytokines. In the present study, apart from antimicrobial activity, in vitro inhibition of MMPs was also proved. The in vitro studies in an established cell line, Hep G2, also indicate that concentra- tions that are typically antimicrobial are non-cytotoxic and would promote scarless wound healing. Further, the acute dermal LD50 value of S-gel in Sprague-Dawley rats, both male and female, was found to be greater than 2000 mg/kg body weight. Also, no mortality or signs of local or systemic toxicity and pathological abnormalities were seen, indicating safety at the highest concentration tested. (49) Wong, K. K. Y.; Tian, J.; Ho, C.; Lok, C.; Che, C.; Che, J.-F.; Tam, P. K. H. Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing. Concurrent Symposium XX: Nanotechnology in Biomedical and Clinical Application. In conclusion, our study offers an unequivocal proof that SNP work as a potent antimicrobial agent at low concentra- tions. In vitro and in vivo experiments established the safety of SNP as well as its formulation (S-gel). The latter could be an effective and safer alternative to conventional topical antimicrobial agents, especially for treating burn wounds. Acknowledgment. The authors acknowledge financial support from Nano Cutting Edge Technology Pvt. Ltd., Mumbai. J.J. thanks Indian Council of Medical Research (ICMR), New Delhi, for a research fellowship. S.A. thanks Council of Scientific and Industrial Research (CSIR), New Delhi, for a research fellowship. The authors are thankful to Interactive Research School for Health Affairs (IRSHA), Pune, for providing animal tissue culture facility and National Center for Cell Sciences (NCCS), Pune, for confocal laser scanning microscopy (CLSM). MP900056G View publication stats VOL. 6, NO. 5 MOLECULAR PHARMACEUTICS 1401PDF Image | Silver Nanoparticles in Therapeutics: Antimicrobial Gel
PDF Search Title:
Silver Nanoparticles in Therapeutics: Antimicrobial GelOriginal File Name Searched:
SilverNanoparticlesinTherapeutics-TopicalUse.pdfDIY PDF Search: Google It | Yahoo | Bing
Turbine and System Plans CAD CAM: Special for this month, any plans are $10,000 for complete Cad/Cam blueprints. License is for one build. Try before you buy a production license. More Info
Waste Heat Power Technology: Organic Rankine Cycle uses waste heat to make electricity, shaft horsepower and cooling. More Info
All Turbine and System Products: Infinity Turbine ORD systems, turbine generator sets, build plans and more to use your waste heat from 30C to 100C. More Info
CO2 Phase Change Demonstrator: CO2 goes supercritical at 30 C. This is a experimental platform which you can use to demonstrate phase change with low heat. Includes integration area for small CO2 turbine, static generator, and more. This can also be used for a GTL Gas to Liquids experimental platform. More Info
Introducing the Infinity Turbine Products Infinity Turbine develops and builds systems for making power from waste heat. It also is working on innovative strategies for storing, making, and deploying energy. More Info
Need Strategy? Use our Consulting and analyst services Infinity Turbine LLC is pleased to announce its consulting and analyst services. We have worked in the renewable energy industry as a researcher, developing sales and markets, along with may inventions and innovations. More Info
Made in USA with Global Energy Millennial Web Engine These pages were made with the Global Energy Web PDF Engine using Filemaker (Claris) software.
Infinity Turbine Developing Spinning Disc Reactor SDR or Spinning Disc Reactors reduce processing time for liquid production of Silver Nanoparticles.
CONTACT TEL: 608-238-6001 Email: greg@infinityturbine.com (Standard Web Page)