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SilVer Nanoparticle Based Formulation for Topical Use articles Wong et al.49 Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, the authors showed that silver nanoparticles exerted positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenetic cytokines. In the present study, apart from antimicrobial activity, in vitro inhibition of MMPs was also proved. The in vitro studies in an established cell line, Hep G2, also indicate that concentra- tions that are typically antimicrobial are non-cytotoxic and would promote scarless wound healing. Further, the acute dermal LD50 value of S-gel in Sprague-Dawley rats, both male and female, was found to be greater than 2000 mg/kg body weight. Also, no mortality or signs of local or systemic toxicity and pathological abnormalities were seen, indicating safety at the highest concentration tested. (49) Wong, K. K. Y.; Tian, J.; Ho, C.; Lok, C.; Che, C.; Che, J.-F.; Tam, P. K. H. Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing. Concurrent Symposium XX: Nanotechnology in Biomedical and Clinical Application. In conclusion, our study offers an unequivocal proof that SNP work as a potent antimicrobial agent at low concentra- tions. In vitro and in vivo experiments established the safety of SNP as well as its formulation (S-gel). The latter could be an effective and safer alternative to conventional topical antimicrobial agents, especially for treating burn wounds. Acknowledgment. The authors acknowledge financial support from Nano Cutting Edge Technology Pvt. Ltd., Mumbai. J.J. thanks Indian Council of Medical Research (ICMR), New Delhi, for a research fellowship. S.A. thanks Council of Scientific and Industrial Research (CSIR), New Delhi, for a research fellowship. The authors are thankful to Interactive Research School for Health Affairs (IRSHA), Pune, for providing animal tissue culture facility and National Center for Cell Sciences (NCCS), Pune, for confocal laser scanning microscopy (CLSM). MP900056G View publication stats VOL. 6, NO. 5 MOLECULAR PHARMACEUTICS 1401PDF Image | Silver Nanoparticles in Therapeutics: Antimicrobial Gel
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