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IbD PU Deliverable 3.1 5.2.2 Coflore® agitated tube reactor (ATR) The Coflore ATR is another variant, which was designed for homogeneous and multi-phase fluids within industrial setting. It uses the same mixing principle as the ACR – a tubular reactor with lateral movement to generate mixing and stage separation to prevent back mixing (Figure 41). Jones et al. (2012) investigated an oxidation reaction catalysed by D-amino acid oxidase operated under benchtop batch mode in an ACR, and the subsequent scale-up in multi-litre continuous production in an ATR. The success of this continuous mode was an important milestone for a previously un-scalable process. Figure 41. The mixing principle of the Coflore agitated tube reactor (ATR) (Jones et al., 2012). 5.3 Impinging stream (IS) reactors The basic principle of impinging streams (IS) is to bring two solid-in-gas (S-I-G) suspension streams to flow in opposite directions at a considerably high velocity and impinge against one another, yielding extremely high relative velocity at the instant of impingement (Elperin, 1972). As such, IS does not involve external agitation but rather agitation is via direct contact of the reacting streams. Over the years, the continuous phase was extended into liquid (L-I- G), with difference in performance (than S-I-G). To make the concept clear, the full definition of IS was proposed by Wu et al. (2010): “Impinging streams are the flow configuration in which two continuous steams with certain momentum fluxes, containing dispersed phase(s) or not, flowing along the opposing directions, respectively, vertical to the bisection across the impinging point, impinge against each other”. 42PDF Image | Solids handling for intensified process technology
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