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IbD PU Deliverable 3.1 particles and reduced the apparent viscosity. The authors concluded that for lower solid concentrations, the surfactant gave a smaller energy utilization, but for higher concentrations, a larger one. Figure 70. A lab-scale stirred ball mill used by Bernhardt et al. (1999). The mill included a stirrer with seven perforated disks. Shakhova et al. (2014) stated that in the cement industry, grinding of raw materials and clinker (binding agent) consumed three quarter of the total electricity costs of the entire process. Additives such as surfactants affect the hydration and crystallization by modifying the cement pore structure, which alter the interface between the cement grain and liquid phase. Grinding aids are organic compounds, added into the mill during grinding to reduce the energy consumption of grinding the clinker into a specified fineness. They also increase the mobility of fine powder during its transportation through pipes, into silos and bins. 9.3 Milling 9.3.1 Wet-stirred media milling In producing drug nanoparticles, wet -stirred media milling (WSMM) has been proven to be an effective technology. Poorly-soluble drug crystals must be reduced in size to improve their dissolution rate and bioavailability. This technique involves stir-mixing a mixture of micron- size drug particles, media (usually beads), and an aqueous solution of stabilizers under very high speeds. Repeated collision between the micron-size particles with the beads causes the size to reduce to nano-scale. This is a function of mixing time. Stabilizers are added to prevent aggregation of the milled particles. Some polymeric stabilizers are added to prevent particle 74PDF Image | Solids handling for intensified process technology
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