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IbD PU Deliverable 3.1 Pharma System, Consigma-25 (Figure 81). This module consists of a wet granulation high shear twin screw and a fluid bed dryer. The quality of granule and the resulting tablet from this module was compared with the product from the batch process. The tests were successful as no deviation of quality was detected. Product quality was constant in function of process time, indicating the stability and repeatability in terms of continuous processing. Figure 81. The Consigma-25 continuous tablet manufacturing equipment consisting mainly of a twin screw wet granulator and a fluid bed dryer (Top). Details of the last part of the twin screw used (Bottom) (Vercruysse et al., 2013). 9.7 Anti-fouling strategies Fouling remediation strategies for the built-in PI modules (RTB, SD, MRT, MAT) are being prepared in a separate document by the Tel-Tek team. Here, a concise overview on fouling/clogging in microchannels and some anti-fouling strategies are presented. This issue could be significant especially in PI plants. 9.7.1 “Ice pigging” for fouling removal Professor Joe Quarini of Bristol University invented a method for cleaning out solid deposits (fouling) in pipelines and heat exchanger tubes using a non-polluting medium: ice. This “ice pig” replaces conventional pigs that are pushed through pipes to clean the interiors, but do not disintegrate in a benign manner, which means that they must be removed at some point along the pipe. The ice pig consists of crushed ice in water with a freezing point depressant. 86PDF Image | Solids handling for intensified process technology
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