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Pharmaceuticals 2020, 13, 66 6 of 10 respectively. A dose dependent toxicity was observed in AgNPs of O. chinensis (Figure 2). The standard plumbagin showed 100% mortality of brine shrimp nauplii at 0.046 mg/mL. Similar to toxicity, the dose dependent anti-inflammatory and anti-diabetic activities were observed in the aqueous and AgNPs’ of O. chinensis ( Figure 3; Figure 4). The AgNPs of O. chinensis showed to be more anti-inflammatory and inhibited the specific enzymes responsible for anti-diabetic activities than the aqueous extracts of O. chinensis (Figures 3 and 4). The anti-inflammatory and anti-diabetic activities of aqueous and AgNPs’ of O. chinensis were statistically significant at p < 0.05 level. The standard indomethacin (100 μg/mL) showed 71.43% inhibition. The standard acarbose 500 μg/mL showed 78% activity. A strong positive correlation was observed with various concentrations of aqueous extracts and anti-inflammatory activity of O. chinensis with the correlation coefficent R = 0.972 and silver nanoparticles of O. chinensis with the correlation coefficent R = 0.965. The correlation was significant at the 0.05 level (2-tailed). A strong positive correlation was observed with various concentrations of aqueous extracts and anti-diabetic activity of O. chinensis with the correlation coefficent R = 0.983 and silver nanoparticles of O. chinensis with the correlation coefficent R = 0.78. The correlation was significant at the 0.05 level Pharmaceuticals 2020, 13, x FOR PEER REVIEW 7 of 11 (2-tailed). Pharmaceuticals 2020, 13, x FOR PEER REVIEW 7 of 11 Figure 2. Toxic potential of the aqueous extracts and AgNPs of O. chinensis. Figure 2. Toxic potential of the aqueous extracts and AgNPs of O. chinensis. Figure 2. Toxic potential of the aqueous extracts and AgNPs of O. chinensis. Figure 3. Anti-inflammatory activity of the aqueous extracts and AgNPs of O. chinensis. Figure 3. Anti-inflammatory activity of the aqueous extracts and AgNPs of O. chinensis. Figure 3. Anti-inflammatory activity of the aqueous extracts and AgNPs of O. chinensis.PDF Image | Synthesis of Silver Nanoparticles Using Odontosoria chinensis
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