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the environment (Weiss, Takhistov, and Clements 2006). NPs have been reported for their application in the nanosensor and nanotracer fields in the food industry (Moraru and others 2003; Jin and others 2009). Moreover, the application of nanotechnology to food packaging has been introduced to improve the shelf life of food and to prevent contamination (Duncan 2011; Maillard and Hartemann 2012). There are increasing numbers of foodborne outbreaks over the world so it is important to control the causes of outbreak. NPs are one of the promising and useful antibacterial agents that could possibly be applied in the food industry. 2.2.1 Antibacterial effect of metal-based NPs Antibacterial agents are of great importance to numerous industries, especially in the food industry. The antibacterial agents currently used in the food industry can be classified into two types: organic and inorganic agents (Zhang and others 2007). Inorganic antibacterial agents, such as NPs have received increasing attention in food applications because they are not only stable under high temperatures and pressures that are typically needed in food-processing conditions, but they are also generally regarded as safe (GRAS) for human beings and animals, relative to organic materials (Sawai 2003; Fu and others 2005). Recent studies show that some NPs have selective toxicity to bacteria but minimal effects on human cells (Reddy and others 2007). Because of these properties, NPs, especially metal-based NPs, have attracted much interest for the control of microorganisms, especially pathogens that cause infectious diseases. There are several factors that influence antibacterial effects of NPs on microorganisms. 5PDF Image | ZINC OXIDE AND SILVER NANOPARTICLES ON INTESTINAL BACTERIA
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