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but other NPs safely in various fields, a detailed understanding of the biocompatibility and toxicity of NPs are needed. 2.4 Intestinal bacteria The human gut is the natural habitat for a large and dynamic bacterial community. Many species of bacteria have evolved and are adapted to live and grow in the human intestine. An individual’s intestine contains 300-500 different species of bacteria (Simon and Gorbach 1984; Borriello 1986). The stomach and small intestine contain only a few species of bacteria adhering to the epithelia and some other bacteria in transit. In contrast, the large intestine contains a complex and dynamic microbial ecosystem with high densities of living bacteria, with concentrations of up to 1011 or 1012 cells/g. These concentrations are similar to those found in colonies growing under optimum conditions over the surface of a laboratory plate (Levison 1990). The constant interaction between the host and its microbial system can infer important health benefits to the human host (Salminen and others, 1998). 2.4.1 Functions of intestinal bacteria Major functions of the gut microflora include metabolic activities, trophic effects, and protective functions (Guarner and Malagelada, 2003). Metabolic activities: A major metabolic function of colonic microflora is fermentation of non-digestible dietary residue and endogenous mucus produce by the epithelia (Roberfroid and others 1995). Various kinds of microbes provide different kinds of enzymes and biochemical pathways that are distinct from the host’s own constitutive 16PDF Image | ZINC OXIDE AND SILVER NANOPARTICLES ON INTESTINAL BACTERIA
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