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Curcumin, a yellow spice and pigment from Curcuma longa L. (Zingiberaceae), is by far known for its antioxidant [1-4], antiinflammatory [4,5] and anticancer [3,4,6,7] activities. Curcumin has proved not to have toxic, genotoxic or teratogenic properties [8-10], so this safe phytonutrient has been widely implied in preclinical and clinical studies [4]. It has been reported that curcumin directly binds to both synthetic and genomic nucleic acids [11]. Also, curcumin interacts strongly with biomacromolecules and the non-covalent interactions are known to play a decisive role in its mechanism of action [12]. Curcumin and its derivatives have shown the ability of being free-radical scavenger, interacting with oxidative cascade, quenching oxygen and chelating and disarming oxidative properties of metal ions [13-15]. Biological activity of curcumin has been attributed to the hydroxyl group substituted on the benzene rings and also to the diketonic structure [16]. The β-diketo moiety of curcumin undergoes a keto–enol tautomerism. Crystal studies [17-19] have shown that the symmetric structure of curcumin leads to a statistically even distribution of the enol proton between the two oxygen atoms. A growing body of evidence indicates that various metals act as catalysts in the oxidative deterioration of biological macromolecules, and therefore, the toxicity associated with these metals may be due at least in part to their ability to generate free radicals [20]. The strong chelating ability of diketones has been widely investigated towards a great number of metal ions; therefore, curcumin could be of great importance in the chelating treatment of metal intoxication and overload. Curcumin forms complexes of the type 1:1 and 1:2 with copper, iron, and other transition metals. This property of binding of curcumin to metals like iron and copper is considered as one of the useful requirements for the treatment of Alzheimer’s disease [21] and it is interesting to note that among the Indian populations, regular usage of turmeric is one of the reasons responsible for the reduced risk of Alzheimer’s disease [21]. 2PDF Image | Electroanalytical dsDNA and curcumin vs copper
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