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J. Funct. Biomater. 2022, 13, 27 3 of 36 Figure 1. Trend of publications in 2DNMS: (a) number of publications of 2DNMS; (b) pie chart showing the contribution of the graphene and beyond graphene 2DNMs in publications; (c) pie chart illustrating the different contribution of 2DNMs beyond graphene in publications; and (d) contribution of each specific 2DNMS beyond graphene in various biomedical applications. The thinness of the 2DNMs also allows them to be useful for a variety of optical ap- plications (e.g., imaging), since the thinness allows them to respond quickly to external signals [19,20]. In addition, it is reported that 2DNMs have plasmonic properties in the near-infrared region which make them an appropriate photothermal agent for photother- mal therapies [17]. Furthermore, the extraordinary mechanical strength and low toxicity of 2DNMs result in a high potential for tissue engineering applications. In fact, the com- bination of such unique optical and mechanical properties increases the biocompatibility of scaffolds and osteogenic differentiation, which are two brilliant features for future tis- sue engineering applications [21]. In this review, the unique properties and the potentials of 2DNMs beyond graphene for various biomedical applications are highlighted. Furthermore, the opportunities and challenges ahead of various biomedical applications as well as biosafety and toxicity eval- uations of 2DNMs beyond graphene are discussed.PDF Image | Nanomaterials beyond Graphene for Biomedical Applications
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