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J. Funct. Biomater. 2022, 13, 27 24 of 36 Figure 13. 2DNMs for wound healing applications. (a) In vivo wound-healing images of cotton gauge (i,v), and Cs-GAP100 (vi,x) nanobiocomposite film (Reprinted with permission from ref. [123]. 2020, American Chemical Society), (b) Exfoliation of graphite to graphene sheets in the hep- tane/G-GMA containing water emulsion and Illustrations of core−skirt architecture of a Boston ker- atoprosthesis (B-KPro) with a typical SEM image of saturable, porous hybrid hydrogel with gra- phene sheets covering the lining of the spherical cavities (Reprinted with permission from ref. [125]. 2021, American Chemical Society), (c) Schematic showing the fabrication of the ZIF-8-laden omniphobic hydrogel membranes by a microfluidic approach and the application of resultant mem- branes for wound healing, (d) photos of the wounds following surgery (0 days), and after11 days of treatment by 500, and 5000 μg mL−1 ZIF-8@PVA omniphobic hydrogel membranes, (e) SEM images showing the porous structure from a top view, and ZIF-8 inside the membranes (Reprinted with permission from ref. [129]. 2020, Wiley-VCH), (f) 3D reconstruction of circular defects and (g,h) Mi- cro-CT images of cranial defect areas (5 mm diameter) at 24 weeks after BGS and TBGS implantation showing the better in vivo osteogenesis performance of TBGS (Reproduced with permission from Ref. [130]. 2019, Wiley-VCH), (i) 3-D schematic of BP/PEA/GelMA Hydrogel Platform with encap- sulated BPNs to enhance Bone Regeneration through Capturing Calcium Ions, (j) SEM images of PEA/GelMA and BP/PEA/GelMA hydrogels after 15 days of mineralization with red indicator min- eral formation (Reprinted with permission from ref. [131]. 2019, American Chemical Society), (k) TEM image of BP nanosheets encapsulated GO nanosheets, and (l) SEM images of varied morphol- ogies of BP and GO on the surfaces of the 3D-PPFAmine-GO@BP scaffold (Reprinted with permis- sion from ref. [132]. 2019, American Chemical Society). 5.5. Photothermal Therapy Photothermal therapy (PTT) is a non-invasive therapeutic technique with the least side effects compared to conventional chemotherapy and radiotherapy methods. In PTT, NIR laser deeply enter tissue and will be absorbed in photothermal agents to locally heat up cells. ThePDF Image | Nanomaterials beyond Graphene for Biomedical Applications
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