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18 Research In vitro In vivo Group 1 Group 2 Group 3 Group 4 Group 5 0 0.125 0.25 0.5 1 2 200 150 100 50 0 0 h 12 h 5 min 35.7°C 35.0°C 35.0°C 52.5°C 52.8°C (a) (b) 24 h 10 min 35.6°C 34.9°C 34.5°C 55.8°C 55.4°C 0.0 0.5 1.0 Concentration (mg/mL) (c) 1.5 2.0 0 min 35.9°C 35.4°C 35.2°C 34.8°C 35.0°C 25 20 15 10 5 0 30 25 20 15 0 2 4 6 8 10 Time (min) (e) Group 1 Group 2 Group 3 (f) Group 4 Group 5 Group 1 Group 2 Group 3 Days Group 4 Group 5 (d) Figure 17: (a) In vitro PA pictures of using B-PEG NSs. (b) PA imaging of tumor sites over time (1, 12, and 24 h) post injection. (c) PA values of using B-PEG NSs. (d) Infrared imaging. (e) Temperature changes with time in the MCF7 tumor-bearing mice after different handlings. (f) The tumor sites of each group were photographed after 14 days of treatment. (g) Changes in body weight were recorded during the experiment. Reprinted with permission from Ref. [62]. Copyright 2018 Wiley-Blackwell. the emerging borophene in the pole position for energy, sen- sor, and biomedical applications. The iterative feedback loop between theoretical and experimental results is widely considered to be the key to expediting the discovery and exploitation of new materials with desired properties. On the basis of theoretical research, the successful synthesis of borophene, along with the genera- tion of other 2D crystal materials which have no layered bulk form, introduces a new way for the production of 2D mate- rials by manipulating the intricate chemistry of materials. The great consistency between theory and experimental practice for borophene indicates that further predictions are needed for future experimental investigations. In the energy-related application of borophene, the good metal properties endow it to be a cathode material for extraordinary energy density in lithium batteries. Boro- phene also shows great potential in the application of bio- sensors. Borophene has different electrical sensitivities to different nucleobases, and it has been developed into a prom- ising application in the sequencing of DNA of biological 10 –2 0 2 4 6 8 10 12 14 16 (g) y=89.04×+5.28 R2=0.9918 𝛥T(°C) Body weight (g) PA signal (a.u.)PDF Image | Two-Dimensional Borophene
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